Where to buy Glutathione Powder with lowering Glutathione price and high quality? Where to find good information of Wholesale Glutathione and Purchase Glutathione for sales? As the professional Glutathione manufacturer, Plamed is your best choice.
Glutathione (GSH), also named Reduced Glutathione, is a tripeptide composed of glutamate, cysteine, and glycine. It can be found in almost every cell of human body. Nowadays, the industrial production of Glutathione is mainly obtained by enzymatic synthesis. In the method, Glutathione has a high purity and good water-solubility. As an active tripeptide with important physiological functions, Glutathione is the most important non-protein sulfhydryl compound in organisms. It has biological activities such as detoxification, anti-oxidation, free radical scavenging, skin-whitening and spot-fading. Therefore, it is widely used in cosmetics, medicine, health care products and other industries. It can be soluble in water greatly and easy to be added into all kinds of skin-whitening cosmetics. Plamed Glutathione is divided into cosmetics grade and medical grade.
|Product Name||CAS Number||INCI Name|
|Molecular Weight||Molecular Formula||Molecular Structure|
|Product ID||Specificcation||Minimal Package||Minimal Order Quantity|
2. Glutathione Source
There are four main methods of preparing Glutathione: enzymatic synthesis, solvent extraction, chemical synthesis and fermentation. Plamed produces Glutathione by enzymatic synthesis. And the product is of high purity and less pollution to environment. It has a good performance-price ratio.
|Enzymatic synthesis||Use L-glutamic acid, L-cysteine and glycine as substrate, and use the natural glutathione synthetase of organisms, then add a little ATP/ADP to synthesize Glutathione||Fast reaction speed, high sensitivity, clear process, but high cost.||High||Low|
|Solvent extraction||Use wheat germ and yeast as raw materials, and then separate and purify to produce Glutathione.||Backward technology, small production scale, low output, low cost.||Higher than that of enzymatic synthesis.||Low|
|Chemical synthesis||Use glutamic acid, cysteine and glycine as raw materials to synthesize Glutathione||Many reaction steps, long reaction time, complex operation and high cost.||Low||Severe|
|Fermentation||Use cheap carbohydrates as raw materials, then convert the materials into glutathione by the metabolism of substances in specific microorganisms||Mild reaction conditions, fast production speed, low cost.||Not high||Low|
3. Reduced Glutathione VS Glutathione Disulfide
|Reduced Glutathione (GSH)||Glutathione Disulfide (GSSG)|
|State||Active state||Inactive state|
|Percentage of glutathione||More than 95%||1% or so|
|Function||Free radical scavenging, anti-aging, skin-whitening||/|
|Application||Whitening and antioxidant cosmetics||/|
|Relation||Reduced Glutathione can convert into GSSG. GSSG’s physiological activity is very low and has little effect, because it accounts for a small proportion. So Glutathione is usually called Reduced Glutathione, and it plays a main role.|
4. Glutathione Specifications
|Glutathione||98% HPLC||White powder|
|Appearance||White or off-white powder|
|Loss on drying||≤0.5%|
|Residue on ignition||≤0.1%|
5. Glutathione Process Flow Chart
6. Glutathione Benefits
- Whiten skin and remove freckle
Glutathione can chelate internal and external toxins such as heavy metals. It can prevent skin pigmentation. Also it can inhibit the formation of new melanin and reduce its oxidation. Glutathione alleviates skin problems such as chloasma. It has a great function of lightening skin and removing freckles. Meanwhile, Glutathione is small molecular peptide. So it can easily penetrate cell membrane and be absorbed by the skin, when applied externally. It is an effective cosmetic ingredient for whitening skin
Glutathione’s structure contains a lively thiol group-SH. So it is easily oxidized and dehydrogenated. The free radicals can be reduced directly into acidic substances by combining the thiol group with free radicals in the body. Thereby it accelerates the elimination of the free radicals; and fight against free radical damage to the skin. At the same time, Glutathione is a kind of radiation protective agent. It can enable radiation to produce highly active free radicals in living organisms through direct and indirect action. And then Glutathione can clear away these free radicals to achieve its anti-oxidant effect.
- Isolate PM2.5
Glutathione can isolate the damage of PM2.5 to the skin, when acting on the skin surface.
7. Pharmacological Studies of Glutathione in Relation to Cosmetics
|Elimination of free radical DPPH||0.1%||Elimination rate：65%|
|Removal rate of superoxide radical||1.0%||Elimination rate：23.1%|
|Inhibition of lipid peroxidation||0.1%||Inhibition rate：40%|
|Inhibition of protein damage under UVA||1mmol/l||Inhibition rate：79.7%|
|Inhibition of hyaluronic acid decrease||1%||Inhibition rate：57.4%|
|Inhibition of the activity of B-16 melanocytes||0.1mg/ml||Inhibition rate：57.1%|
|Inhibition of tyrosinase activity||0.1mg/ml||Inhibition rate：83.5%|
8. Plamed Glutathione Characteristic
- Glutathione has a good water-solubility, and it is easy to prepare cosmetics;
- The extraction process is safe and effective, without residual pollutants.
9. Glutathione Application and Reference Dosage
Glutathione is mainly used in whitening skin care products, such as serum, facial mask, emulsion, toner, essence, cream, etc.
- Glutathione cannot be used with vitamin B12, orotic acid (vitamin B13) into cosmetics, or it will cause skin irritation.
Glutathione application cases in major cosmetic brands in the world:
|Korea||Cindella||Cindeltox white cream|
|Secret key||Snow White Cream|
|Dr. Althea||Power Whitening Glutathione Cream|
|Claires||Guerisson 9 Complex, Essence|
|G9skin||White In Milk Whipping Foam, cream , eye cream，sun, serum|
|Wishtrend||Hours-Long Moisturizing Gauze Sheet Mask|
|Papa Recipe||Bombee Whitening Honey Mask Pack|
|Klavuu||Marine Collagen Micro Cleansing Water|
|USA||Relumins||Glutathione toner, essence, body whitening cream|
|Kirkman||Reduced L-Glutathione Lotion|
|Swanson||L-Glutathione Cream with Setria|
|BeShiny||Glutathione Skin Whitening Brightening Serum|
|Thailand||Mistine||Intensive Whitening Facial Cream, utathione Intensive Whitening Serum|
|Shouvy||Whitening Body Lotion, ening Bleaching Soap|
|Cathy Doll Karmart||L-glutathione Magic sunscreen|
|France||ATrue||Watery Calming Cream|
10. Glutathione Reference Formula
|Ingredient||Content (Mass)||Ingredient||Content (Mass)|
|Glutathione||54||Aloe Vera Extract||54|
|Papaya extract||50||Sesame oil||54|
|Black bean estroge||50||Blackberrglily Rhizome Extract||54|
|Lubrajel oil||50||Ophiopogonis japonicus P.E||50|
|D- panthenol||50||1,2- octylene glycol||54|
|Guar gum||52||Nigella damascena extract||54|
|Cocoa butter||54||Sorbitan octanoate||50|
|Codium tomentosum extract||50||Water||2000|
|Glutathione||0.5||Phosphoric acid cetyl ester diethanolamine||2.0|
|Isopropyl palmitate||12.0||Ascorbyl palmitate||0.2|
|2- 16/18 glycol||2.0||Acetic acid||0.2|
|Lanonol||3.0||Butyl methoxydibenzoyl methane||1.0|
|Refined water||Add to 100|
11. Glutathione Safety
- CTFA has recognized Glutathione as a raw material for cosmetics;
- The International Catalogue of Chinese Cosmetic Raw Materials Standards in 2010 issued by CAFFCI and On the Announcement of Name List of Cosmetics Raw Material published by CFDA in 2014 both include Glutathione. There are no reports indicating that Glutathione is unsafe for external use.
12. Packing and Storage
Package: Packed in 25kg paper drums with two plastic bags inside.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
Plamed Mission: To be the most professional supplier of natural cosmetics raw material.
As a professional Glutathione manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Glutathione and good Glutathione price will help customers make good terminal products and help customers win a lasting and broad market.
Other Skin-whitening Product List
|NO.||Product Name||Product ID||Specification||Product Image|
|03||Kojic Acid Dipalmitate||PMB0801||99%|
|04||D-alpha Tocopherol Acetate||PMB0901|
|06||Grape seed extract||PMB1401||95%OPC|
|10||Ascorbic Acid 2-Glucoside (AA2G)||PMB1801||98%|
|14||Green Tea Extract||PMB1501, PMB1502, PMB1503||95% EGCG, |
70% oil-soluble polyphenols,
98% water-soluble polyphenols