Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.
Ergothioneine (EGT) is a natural amino acid with potent antioxidant activity. It is a water-soluble cosmetic raw material; it has good light and heat stability, and is not easily decomposed by oxidation. Therefore, ergothioneine is easy to be compatible with other active materials in cosmetics formulas. Moreover, ergothioneine is non-toxic in epidermal cells, so it will not produce any irritation when used topically with safety and effectiveness. Ergothioneine is a natural ultraviolet protective agent, which can block the damage of ultraviolet rays to the skin, and play a role in sun protection. It can also repair damaged collagen and elastic fibers. Ergothioneine can also effectively remove high-concentration free radicals in the human body, whiten the skin, and delay skin aging. Studies have shown that when ergothioneine is used together with other antioxidants, it has a good synergistic whitening and anti-aging effect.
| Product Name | CAS Number | INCI Name | |
| Ergothioneine | 497-30-3 | ERGOTHIONEINE | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| 229.3g/mol | C9H15N3O2S |  |
|
| Product ID | Specification | Minimal Package | Minimal Order Quantity |
| PMKZ2101 | 99% | 10g | 10g |
In 1909, ergothioneine was first discovered in Claviceps purpurea. Later, it was also found in animals’ organ. At present, there are three main sources of ergothioneine. They are chemical synthesis, biosynthesis, and animal and plant extraction. Microorganisms such as spirulina, ascomycetes, mycobacteria, and basidiomycetes can bio-synthesize ergothioneine. At the same time, ergothioine is also present in the fruiting bodies of edible fungi, such as bisporus, oyster mushroom. Nowadays, biosynthesis is mostly used for large-scale production of ergothioneine. Ergothioneine produced by this method has high purity and few impurities.
| Product Name | Specification | Color |
| Ergothioneine | 99% | White powder |
| Items | Specification |
| Purity | ≥99% HPLC |
| Appearance | White to off-white powder |
| Physical Characteristics | |
| Loss in drying | ≤3.0% |
| Particle size | 98% pass 100 mesh |
| Heavy Metals | |
| Pb | ≤10ppm |
| As | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤5ppm |
| Microbiological Tests | |
| Total plate count | ≤100cfu/g |
| Yeast & mold | ≤50cfu/g |
| Pseudomonas aeruginosa | Not detected |
| Staphylococcus aureus | Not detected |
| Heat-resistant escherichia coli | Not detected |
Ergothioneine has anti-oxidation ability. Under the condition of continuous ultraviolet irradiation for 18 hours, 70% of the cells are still reductive, because of ergothioneine’s exist. Ergothioneine inhibits lipid per-oxidation, prevents the production of active oxides, and reduces the apoptosis of irradiated cells. Thereby it can prevent skin aging and effectively improve fine lines and wrinkles.
A study use emulsion containing 2.0% EGT once a day for 4 weeks. As a result, the participant’s skin wrinkles reduce significantly, and the skin becomes more bright. Show as following picture.
Another study compares the ability scavenging free radicals among EGT, coenzyme Q10, and idebenone. It indicates that EGT’s antioxidant activity is better than that of coenzyme Q10 or idebenone. Ergothioneine is relatively more effective in removing free radicals and protecting cells from UV inducing of ROS.
In the ultraviolet absorption range, ergothioneine has an absorption wavelength similar to that of DNA, with a molar extinction coefficient of 1.4*104 M-1 cm-1, λmax257. It can decrease the formation of reactive oxygen species and protect skin cells from UV-radiation damage. Therefore, ergothioneine can be used as a physiological filter of ultraviolet rays; it can avoid the damage caused by ultraviolet rays to the skin. In a word, ergothioneine is a very effective sunscreen ingredient.
| Test Items | Concentration | Result |
| Elimination of free radical singlet oxygen | Elimination rate: 2.3×107/mL-1 | |
| Elimination of hydroxyl radicals | Elimination rate: 1.2×1010/mL-1 | |
| Elimination of free radical DPPH | IC50 : 53μg/mL | |
| Inhibition of keratinocyte apoptosis under high concentration of ozone | 1mmol/L | Inhibition rate: 48.6% |
| Inhibition of fibroblast apoptosis under UVB irradiation | 1mmol/L | Inhibition rate: 70% |
| Inhibition of tyrosinase activity | 0.1% | Inhibition rate: 48% |
| Inhibition of glycosylation of skin proteins | 5mmol/L | Inhibition rate: 42.9% |
| Inhibition of lipase activity | IC50: 0.221mg/mL | |
| Inhibition of 5α-reductase activity | IC50: 2.32mg/mL |
Ergothioneine is mainly used in whitening skin care products, such as serum, facial mask, emulsion, toner, essence, cream, etc.
| Product | Reference Dosage |
| Ergothioneine | 0.01%-3.0% |
In different functional cosmetics, Ergothioneine has different dosage.
| Items | Reference Dosage |
| Cream | 0.01-1.0% |
| Emulsion | 0.01-2.0% |
| Toner | 0.01-3.0% |
Ergothioneine application cases in major cosmetic brands in the world
| Country | Brand | Product |
| Switzerland | La Prairie | Skin Caviar Essence In Lotion |
| Spain | ISDIN | Daily Antioxidant Serum |
| USA | Origins | Mega-Mushroom Relief & Resilience Soothing Treatment Lotion |
| Estee Lauder | Global Anti-Aging Creme
Radiant Vitality 2-In-1foam Cleanser Intense Reset Concentrate |
|
| Elizabeth Arden | Prevage Anti-Aging Daily Serum 2.0 | |
| Clinique | Turnaround Revitalizing Lotion | |
| China | Proya | Elastic Brightening Youth Essence
Elastic Brightening Youth Activating Eye Cream |
| UMOUA | Liposome Peptide Tech Eye Cream | |
| HBN | Ergothionein Brightening Essence |
Toner
| Ingredient | Content (%) | Ingredient | Content (%) |
| Ergothioneine | 0.02 | Xanthan Gum | 0.1 |
| Trehalose | 1.0 | Glycerin | 8.0 |
| Propylene Glycol | 7.0 | Water-Soluble Lanolin | 3.0 |
| Fragrance | 0.1 | Hydrogenated Castor Oil | 1.0 |
| Preservative | 0.2 | Deionized Water | Add To 100 |
Emulsion
| Ingredient | Content (%) | Ingredient | Content (%) |
| Ergothioneine | 0.1 | Brij-72 | 1.2 |
| Brij-721 | 1.5 | Hexyldecyloctadecanol | 0.5 |
| Simethicone | 3.0 | Hydrogenated Castor Oil | 3.5 |
| Octyl/Decyl Triglyceride | 4.0 | White Oil | 3.0 |
| BHT | 0.05 | Propylene Glycol | 6.0 |
| Glycerin | 8.0 | Carbomer 20 | 10.0 |
| Preservative | 0.2 | Fragrance | 0.2 |
| Na-OH | Q.s. | Water | Add to 100 |
Package: 10g/bag, 100g/bag, 1kg/bag.
Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.
A: To meet strict global standards and diverse market needs, our cosmetic ingredients are certified under major international systems:
ISO 9001:2015 (Quality Management System): Guarantees that our manufacturing processes—from raw material sourcing to final production—adhere to strict quality control standards. Ensures consistent batch-to-batch stability, which is essential for our clients in the Europe and US markets looking for premium, compliant, and reliable supply chains.
Halal Certification: Fully certified Halal, ensuring compliance with strict ingredient traceability and the absence of prohibited substances or cross-contamination.
Allows our partners to seamlessly enter and expand in the Southeast Asian (e.g., Indonesia, Malaysia) and Middle Eastern markets, meeting local regulatory mandates.
We are committed to providing fully traceable, high-quality, and compliant ingredients to support your brand’s global growth. If you need copies of our certificates or specific technical documentation (such as COA, MSDS, or compliance statements), please feel free to contact our team.
A: Yes, absolutely. Regulatory compliance and safety are our top priorities. All of our premium active ingredients have standard, internationally recognized INCI names and are fully compliant with the stringent regulations of these major markets:
European Union: Fully compliant with the EU Cosmetic Regulation (EC) No 1223/2009, including safety assessments, and banned/restricted substance lists.
United States: Formulated and manufactured in strict accordance with FDA guidelines and the latest MoCRA (Modernization of Cosmetics Regulation Act) requirements, ensuring smooth product registration and listing.
South Korea: Compliant with the regulations set by the MFDS (Ministry of Food and Drug Safety), meeting their strict standards for functional cosmetic ingredients and efficacy documentation.
Whether you are a distributor or a brand owner in Europe, the Americas, or Southeast Asia, you can seamlessly integrate our ingredients into your formulations. We provide comprehensive regulatory support dossiers (COA, TDS, MSDS, and Composition Statements) to facilitate your local product promotion.
A: Yes, we provide comprehensive efficacy dossiers for all our flagship ingredients (such as PMSoothe® Kava97, PCR® Supermolecule Escin, and PMRefresh® Willow). Our data packages include:
In-vitro (cell-based) test reports to demonstrate cellular-level activihttphttp://zhitiye.com/product/anti-irritating-cosmetics-ingredient-pmsoothe-kava97/://zhitiye.com/product/anti-irritating-cosmetics-ingredient-pmsoothe-kava97/ty and pathways.
In-vivo (human clinical) trial data to prove real-world visible results.
Safety assessments and clear Mechanism of Action (MOA) diagrams.
These rigorous, science-backed materials are designed to help our distributors easily convince formulation chemists and premium brand owners.
A: Absolutely. We support our partners’ R&D efforts through a two-step support system:
Free Samples: We provide complimentary samples for laboratory evaluation and pilot trials.
Technical & Formulation Support: To accelerate your application process, we will also provide formulation guides for you.
Our dedicated technical support team is also available to help your customers resolve challenges related to formulation stability, compatibility, and optimal dosage.
A: We empower our global distributors with a comprehensive suite of “Turn-key” Marketing Kits to minimize your promotional costs and time-to-market. Our support includes:
Technial Documentation: Product brochures, white papers, and TDS, MSDS, and COA.
Visual Materials: Ingredient videos and ready-to-use social media posters.
Market Intelligence: Detailed competitive analysis reports and trend insights.
Co-Marketing: We also attend at major international cosmetics exhibitions to boost local brand awareness.
A: Yes, we strictly adhere to a win-win, distributor-first channel policy:
Any direct inquiries, sample requests, or business leads received through our website or international trade shows from an authorized region will be precisely forwarded to our local exclusive or authorized distributor.
We protect your market efforts and actively help you convert local brand clients into long-term order.
A: We offer highly flexible logistical terms to support your business:
Minimum Order Quantity (MOQ): For most of our active ingredients, the MOQ is as low as 1 kg, allowing high flexibility for your inventory management.
Lead Time: Our standard lead time is highly competitive. Products are typically dispatched within 3 to 5 working days upon receipt of payment, subject to specific product availability and shipping logistics.
A: We maintain an open, strategic, and highly supportive attitude toward building exclusive global partnerships. We evaluate potential distributors based on:
Local distribution channels and market expertise.
Annual purchase volume projections.
Market expansion and promotional plans.
If you are interested in growing with us, please click the [Apply Now] to contact our business manager, and we will answer everything you would like to know.
Click the button to get the full product report.
